New Paper!

Congratulations to Dr. Qing Yan, who is co-advised by Jeff Chang and Dr. Joyce Loper (USDA-ARS), on his recent publication! In this paper, Qing reports on the enrichment of rare codons in pltR, a transcriptional regulator of pyoluteorin biosynthesis genes. He further showed that a substitution mutant (he changed 23 codons) with "optimized" codons and a strain that overexpressed the cognate tRNA for the rare AGA codon, had increased levels of pyoluteorin. In total, the data suggest that the abundance of rare codons limits the expression of pyoluteorin, likely to prevent fitness defects.